Characterization and manipulation of foamy virus membrane interactions
نویسندگان
چکیده
منابع مشابه
Characterization of provirus clones of simian foamy virus type 1.
We have cloned proviral DNA of simian foamy virus type 1 (SFV-1) from linear unintegrated DNA (pSFV-1). Transfection of pSFV-1 induces cytopathology in several cell lines with supernatants from the transfected cell culture containing infectious viral particles. Electron microscopy of the transfected cells revealed foamy virus particles. Deletion analysis of pSFV-1 indicated that the transcripti...
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15 صفحه اولFurther characterization of equine foamy virus reveals unusual features among the foamy viruses.
Foamy viruses (FVs) are nonpathogenic, widely spread complex retroviruses which have been isolated in nonhuman primates, cattle, cats, and more recently in horses. The equine foamy virus (EFV) was isolated from healthy horses and was characterized by molecular cloning and nucleotide sequence analysis. Here, to further characterize this new FV isolate, the location of the transcriptional cap and...
متن کاملFoamy Virus Protein—Nucleic Acid Interactions during Particle Morphogenesis
Compared with orthoretroviruses, our understanding of the molecular and cellular replication mechanism of foamy viruses (FVs), a subfamily of retroviruses, is less advanced. The FV replication cycle differs in several key aspects from orthoretroviruses, which leaves established retroviral models debatable for FVs. Here, we review the general aspect of the FV protein-nucleic acid interactions du...
متن کاملFoamy Virus Budding and Release
Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction of the capsid protein with components of cellular vacuolar protein sorting (Vps) machinery via late domains identified in some FV capsid protei...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2012
ISSN: 1462-5814
DOI: 10.1111/cmi.12042